The Indiana Hoosiers (3-1) play the Louisville Cardinals (2-2) on Monday, November 20, 2023 at 4:30 PM ET. The matchup airs on ESPNU. In this preview, we analyze the Indiana vs. Louisville odds and lines for this matchup.

The Hoosiers are a 7-point favorite against the Cardinals when the Hoosiers and the Cardinals meet. The point total for the game is 145.5.

Indiana covered 16 times in 35 matchups with a spread last season. Louisville compiled a 13-19-0 ATS record last year.

Here is everything you need to get ready for Monday’s college basketball action.

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Indiana at Louisville odds, spread and lines

College basketball odds courtesy of BetMGM Sportsbook. Odds updated Monday at 5:12 AM ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

  • Spread: Indiana -7
  • Total: 145.5
  • Moneyline: Indiana -294, Louisville +238

Indiana vs. Louisville prediction

Louisville 77, Indiana 70


  • Indiana finished 19-6 in games it was favored on the moneyline last season (winning 76% of those games).
  • The Hoosiers won all eight games they played as a moneyline favorite with odds of -294 or shorter.
  • Indiana has an implied moneyline win probability of 74.6% in this matchup.
  • Last season, Louisville won three out of the 28 games, or 10.7%, in which it was the underdog.
  • Last season, the Cardinals won two of their 24 games, or 8.3%, when they were an underdog by at least +238 on the moneyline.
  • The implied probability of a win by Louisville, based on the moneyline, is 29.6%.

Against the spread

  • Indiana covered 16 times in 35 games with a spread last season.
  • Louisville won 13 games against the spread last year, while failing to cover 19 times.
  • Last year, the Hoosiers averaged 74.7 points per game, just 1.1 fewer points than the 75.8 the Cardinals allowed.
  • Indiana had a 10-4-1 record against the spread and a 14-2 record overall last season when putting up more than 75.8 points.
  • Louisville went 4-6 against the spread and 3-7 overall last season when giving up fewer than 74.7 points.
  • The Cardinals averaged only 4.8 fewer points per game last year (63.9) than the Hoosiers gave up to opponents (68.7).
  • When it scored more than 68.7 points last season, Louisville went 7-1 against the spread and 2-6 overall.
  • Indiana went 6-3 against the spread and 9-1 overall last season when it gave up fewer than 63.9 points.
  • The Hoosiers scored a total of 212 more points than their opponents last year (an average of six per game), while the Cardinals were out-scored by opponents on average last year (by 379 total points, -11.9 per game).


  • The Hoosiers had an average implied point total of 75.3 last season, which is 0.7 points lower than their implied total in Monday’s game (76).
  • Last season, Indiana scored more than 76 points in 16 games.
  • The 74.7-point average implied total last season for the Cardinals is 5.7 more points than the team’s 69-point implied total in this matchup.
  • Louisville totaled more than 69 points in a game three times last year.